Background: The care workforce includes paid and unpaid carers. Caring can be physically and mentally demanding - for paid carers this may result in poor staff retention whilst for unpaid carers this may impact on their capacity to engage in the labour market. However, exactly how work and health relate to one another in the un/paid care workforce remains unclear. Methods: This study triangulates findings from a two-part scoping review and a semi-structured interview study with paid and unpaid carers across the UK. Four online databases were searched in October 2025. Interviews were conducted between October 2025 and March 2026. Data were analysed using reflexive thematic analysis. Through public stakeholder consultations, we developed the novel Carers Work and Health Support Model. Findings: Analysis of the evidence on paid carers (24 Studies from 15 countries) and unpaid carers (58 studies from 18 countries) revealed clear work-related impacts on the mental and physical health of paid and unpaid carers. Most evidence focussed on negative mental health outcomes, including stress, anxiety, depression, and burnout, with muskoloskeletal issues, back, neck, and head pain, and sleep disturbances also often evidenced. These were corroborated by the interviews with 31 carers. The Carers’ Work and Health Support Model is the first to detail how different work-related factors for both carers influence mental and physical health. Conclusions: Findings indicate clear avenues for work- and health-related interventions to maintain a healthy and productive paid and unpaid care workforce.