Antibiotic-Associated Harms in Older Adults in Residential Aged Care Facilities (RACFs): Definitions, Measures, and Outcome: A Scoping Review
Aathira Suvi Bright Jose

Date and Time

Wednesday, November 11, 2026

Theme / Track

Health, medical and integrated care

Presentation Format

Poster Presentation
Background: Antibiotics are frequently prescribed in residential aged care facilities (RACFs), with up to 70% of residents receiving systemic antibiotics annually (Mody et al., 2015; Nicolle et al., 2000). Older adults are particularly vulnerable to antibiotic-associated harms due to multimorbidity, polypharmacy, frailty, and age-related physiological changes (Gutiérrez-Valencia et al., 2018; Pazan & Wehling, 2021). However, evidence remains fragmented, with inconsistency in how harms are defined and measured. Aims: To map the types of antibiotic-associated harms reported among older adults in RACFs, and to examine how these harms are defined, operationalised, and measured. Methods: This scoping review follows Arksey and O’Malley (2005), refined by Levac et al. (2010) and Peters et al. (2020), and is reported according to PRISMA-ScR (Tricco et al., 2018). A systematic search of Medline (n=238), CINAHL (n=155), EmCare (n=256), Scopus (n=181), and Web of Science (n=3), supplemented by handsearching (n=1), identified 834 records. Following duplicate removal, records were screened for eligibility, with full-text review and data extraction underway. Preliminary Findings: Early screening indicates substantial heterogeneity in reported harms and outcome measures. Frequently identified harms include antibiotic-associated diarrhoea, Clostridioides difficile infection, adverse drug reactions, and antimicrobial resistance outcomes, with inconsistent definitions and measurement approaches across studies. Conclusions/Implications: This review will provide a comprehensive evidence map of antibiotic-associated harms in RACF populations, informing future research and antimicrobial stewardship initiatives in aged care.

Keywords

Chronic Conditions, Evidence Based Practice, Literature, Medications, Residential

Authors

Andreia Schineanu, BSc, PG. Dip Biomed Sci, MSW, PhD, School of Nursing, Paramedicine and Healthcare Sciences, Charles Sturt University, Wagga Wagga, New South Wales, 2678, Australia.
George K. John, B.Pharm, M. Pharm. Prac, GCPM, GCDM, School of Dentistry & Medical Science, Charles Sturt University, Wagga Wagga, New South Wales, 2678, Australia, Murrumbidgee Local Health District, Wagga Wagga, New South Wales, 2650, Australia.